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Muscle Nerve. 2010 Oct;42(4):600-3. doi: 10.1002/mus.21763.

Gender influences cardiac function in the mdx model of Duchenne cardiomyopathy.

Author information

1
Department of Molecular Microbiology and Immunology, School of Medicine, 1 Hospital Drive, Columbia, Missouri 65212, USA.

Abstract

Aged mdx mice represent an important model for studying Duchenne cardiomyopathy. Herein we compared the cardiac phenotypes of 22-month-old male and female mdx mice. Surprisingly, only females displayed the characteristic cardiac dilation on pressure-volume loop analysis. Female mdx mice also exhibited lower contractility, larger Q waves, and higher ratios of heart weight to body weight. Our results reveal significant gender disparity in mdx cardiac function. Gender should be considered when using the mdx model for the study of Duchenne cardiomyopathy.

PMID:
20878741
PMCID:
PMC3109082
DOI:
10.1002/mus.21763
[Indexed for MEDLINE]
Free PMC Article

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