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Int J Biol Markers. 2010 Jul-Sep;25(3):157-63.

Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study.

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1
Centro Nacional de Vigilancia Epidemiológica y Control de Enfermedades, SSA, Mexico City, Mexico.

Abstract

BACKGROUND:

Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis.

OBJECTIVE:

The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease.

MATERIAL AND METHODS:

A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP.

RESULTS:

The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found.

CONCLUSIONS:

This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.

PMID:
20878621
[Indexed for MEDLINE]

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