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Chem Commun (Camb). 2010 Nov 21;46(43):8174-6. doi: 10.1039/c0cc03148h. Epub 2010 Sep 28.

Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.

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1
Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA.

Abstract

Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

PMID:
20877851
DOI:
10.1039/c0cc03148h
[Indexed for MEDLINE]
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