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Nat Neurosci. 2010 Oct;13(10):1161-9. doi: 10.1038/nn.2647. Epub 2010 Sep 27.

Animal models of neuropsychiatric disorders.

Author information

1
Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA. eric.nestler@mssm.edu

Abstract

Modeling of human neuropsychiatric disorders in animals is extremely challenging given the subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests, and the early state of the relevant neurobiology and genetics. Nonetheless, progress in understanding pathophysiology and in treatment development would benefit greatly from improved animal models. Here we review the current state of animal models of mental illness, with a focus on schizophrenia, depression and bipolar disorder. We argue for areas of focus that might increase the likelihood of creating more useful models, at least for some disorders, and for explicit guidelines when animal models are reported.

PMID:
20877280
PMCID:
PMC3750731
DOI:
10.1038/nn.2647
[Indexed for MEDLINE]
Free PMC Article

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