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J Clin Invest. 2010 Oct;120(10):3437-40. doi: 10.1172/JCI44721. Epub 2010 Sep 27.

In obesity and weight loss, all roads lead to the mighty macrophage.

Author information

1
Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.

PMID:
20877005
PMCID:
PMC2947244
DOI:
10.1172/JCI44721
[Indexed for MEDLINE]
Free PMC Article

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