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FEBS Lett. 2010 Dec 15;584(24):4878-82. doi: 10.1016/j.febslet.2010.09.029. Epub 2010 Sep 28.

The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.

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1
Integrated Department of Immunology, University of Colorado School of Medicine, Denver CO 80206, USA.

Abstract

Immunoreceptor signals must be appropriately transduced and regulated to achieve effective immunity while controlling inflammation and autoimmunity. It is generally held that these processes are mediated by the interplay of distinct activating and inhibitory receptors via conserved activating (ITAM) and inhibitory (ITIM) signaling motifs. However, recent evidence indicates that under certain conditions incomplete phosphorylation of ITAM tyrosines leads to inhibitory signaling. This new regulatory function of ITAMs has been termed ITAMi (inhibitory ITAM). Here we discuss the potential molecular mechanisms of inhibitory signaling by ITAM-containing receptors.

PMID:
20875413
PMCID:
PMC2998577
DOI:
10.1016/j.febslet.2010.09.029
[Indexed for MEDLINE]
Free PMC Article
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