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Emerg Infect Dis. 2010 Oct;16(10):1633-6. doi: 10.3201/eid1610.100688.

Emergence of oseltamivir-resistant pandemic (H1N1) 2009 virus within 48 hours.

Author information

1
Agency for Science, Research and Technology, Singapore.

Abstract

An oseltamivir-resistant influenza A pandemic (H1N1) 2009 virus evolved and emerged from zero to 52% of detectable virus within 48 hours of a patient's exposure to oseltamivir. Phylogenetic analysis and data gathered by pyrosequencing and cloning directly on clinical samples suggest that the mutant emerged de novo.

PMID:
20875299
PMCID:
PMC3294403
DOI:
10.3201/eid1610.100688
[Indexed for MEDLINE]
Free PMC Article

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