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Biomarkers. 2010 Dec;15(8):663-70. doi: 10.3109/1354750X.2010.509811. Epub 2010 Sep 29.

Alkaline phosphatase and percentage body fat predict circulating C-reactive protein in premenopausal women.

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1
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555-1109, USA.

Abstract

C-reactive protein (CRP) is considered a marker of inflammation, which is a risk factor for many chronic diseases. However, determinants of CRP remain unclear and were studied in a strictly defined cohort of healthy premenopausal women (n=233) using multiple regression models. Independent predictors of serum CRP (model R(2)=0.59) were percentage body fat, serum alkaline phosphatase (ALP), sex hormone-binding globulin and white blood cell count. The close association between CRP and ALP suggests that enzymatic activity of ALP may be important for the anti-inflammatory effects of CRP, which should be confirmed with additional studies.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00204477.

PMID:
20874659
PMCID:
PMC2981667
DOI:
10.3109/1354750X.2010.509811
[Indexed for MEDLINE]
Free PMC Article

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