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Arch Microbiol. 2010 Dec;192(12):1019-22. doi: 10.1007/s00203-010-0633-1. Epub 2010 Sep 26.

Inhibition of Vibrio cholerae biofilm by AiiA enzyme produced from Bacillus spp.

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Cholera and Environmental Microbiology Lab, Department of Molecular Microbiology, Rajiv Gandhi Centre for Biotechnology, Trivandrum, Kerala 695014, India.


Vibrio cholerae is the causative agent of water-borne diarrheal disease, cholera. The formation of biofilm favors survival and persistence of V. cholerae in the aquatic environment and also inside the host. AHL lactonase (AiiA), a metallo-beta-lactamase produced by Bacillus spp., blocks quorum sensing in Gram-negative bacteria by hydrolyzing N-acyl-homoserine lactones (AHLs). In the present investigation, AiiA-mediated inhibition of V. cholerae biofilm was studied. Two novel alleles of aiiA-encoding genes from Bacillus spp. were expressed in E. coli, and the results demonstrated that AiiA enzyme is a potent inhibitor of V. cholerae biofilm.

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