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Arch Gynecol Obstet. 2011 Aug;284(2):411-9. doi: 10.1007/s00404-010-1689-5. Epub 2010 Sep 26.

Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms.

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Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital, Dusit District, Bangkok, Thailand.



To compare Pueraria mirifica 25 and 50 mg dosages to relieve menopausal symptoms.


A double-blind study was conducted on 52 hysterectomized women with menopausal symptoms who had an indication for hormone therapy. The women were randomly allocated into two groups receiving either Pueraria mirifica 25 mg tablet (Arm A; n = 26) or Pueraria mirifica 50 mg (Arm B; n = 26) for 6 months. Menopausal symptoms, physical examination findings, and laboratory data were recorded at baseline. Symptoms were reevaluated at 3 and 6 months, while physical and laboratory examinations were evaluated at 1 month and at the end of treatment. A modified Green climacteric scale was used to evaluate menopausal symptoms; a score of ≥ 15 indicated estrogen deficiency.


All women completed the study. Mean baseline climacteric scores of women who received 25 and 50 mg were: 24.19 ± 9.11 versus 23.19 ± 7.89, respectively (p = 0.674). After 3 and 6 months of treatment, scores were 17.92 ± 10.40 versus 15.35 ± 8.44 (p = 0.332) and 14.08 ± 10.30 versus 12.46 ± 6.38 (p = 0.500), respectively. No significant side effects were observed with Pueraria mirifica 25 or 50 mg.


Both dosages of Pueraria mirifica were similarly effective and safe in the treatment of menopausal symptoms.

[Indexed for MEDLINE]

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