Send to

Choose Destination
See comment in PubMed Commons below
Neurocomputing. 2003 Jun 1;52-54:955-961.

Reliability and bifurcation in neurons driven by multiple sinusoids.

Author information

  • 1Computational Neurobiology Lab, Howard Hughes Medical Institute, Sloan-Swartz Center for Theoretical Neurobiology, La Jolla, CA, USA.


The brain produces dynamical rhythms at many frequencies that shift in amplitude and phase. To understand the functional consequences of mixtures of oscillations at the single cell level, we recorded the spike trains from single rat cortical neurons in vitro in response to two mixed sine wave currents. The reliability of spike timing was measured as a function of the relative power, phase and frequencies of the sine wave mixture. Peaks in the reliability were observed at a preferred phase difference, frequency and relative power. These results have a natural interpretation in terms of spike train attractors and bifurcations.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center