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Clin Neurophysiol. 2011 May;122(5):1011-8. doi: 10.1016/j.clinph.2010.08.016.

The theoretical model of theta burst form of repetitive transcranial magnetic stimulation.

Author information

1
Department of Neurology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taipei 10507, Taiwan. yzhuang@adm.cgmh.org.tw

Abstract

OBJECTIVE:

Theta burst stimulation, a form of repetitive transcranial magnetic stimulation, can induce lasting changes in corticospinal excitability that are thought to involve long-term potentiation/depression (LTD/LTD)-like effects on cortical synapses. The pattern of delivery of TBS is crucial in determining the direction of change in synaptic efficiency. Previously we explained this by postulating (1) that a single burst of stimulation induces a mixture of excitatory and inhibitory effects and (2) those effects may cascade to produce long-lasting effects. Here we formalise those ideas into a simple mathematical model.

METHODS:

The model is based on a simplified description of the glutamatergic synapse in which post-synaptic Ca(2+) entry initiates processes leading to different amount of potentiation and depression of synaptic transmission. The final effect on the synapse results from summation of the two effects.

RESULTS:

The model using these assumptions can fit reported data. Metaplastic effects of voluntary contraction on the response to TBS can be incorporated by changing time constants in the model.

CONCLUSIONS:

The pattern-dependent after-effects and interactions with voluntary contraction can be successfully modelled by using reasonable assumptions about known cellular mechanisms of plasticity.

SIGNIFICANCE:

The model could provide insight into development of new plasticity induction protocols using TMS.

PMID:
20869307
PMCID:
PMC3046904
DOI:
10.1016/j.clinph.2010.08.016
[Indexed for MEDLINE]
Free PMC Article
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