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Reprod Toxicol. 2011 Jan;31(1):41-9. doi: 10.1016/j.reprotox.2010.09.002. Epub 2010 Sep 22.

Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy.

Author information

1
Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Claudia.Kappen@pbrc.edu

Abstract

Pregnancies complicated by maternal diabetes have long been known to carry a higher risk for congenital malformations, such as neural tube defects. Using the FVB inbred mouse strain and the Streptozotocin-induced diabetes model, we tested whether the incidence of neural tube defects in diabetic pregnancies can be modulated by maternal diet. In a comparison of two commercial mouse diets, which are considered nutritionally replete, we found that maternal consumption of the unfavorable diet was associated with a more than 3-fold higher rate of neural tube defects. Our results demonstrate that maternal diet can act as a modifier of the risk for abnormal development in high-risk pregnancies, and provide support for the possibility that neural tube defects in human diabetic pregnancies might be preventable by optimized maternal nutrition.

PMID:
20868740
PMCID:
PMC3035722
DOI:
10.1016/j.reprotox.2010.09.002
[Indexed for MEDLINE]
Free PMC Article

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