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Phys Rev Lett. 2010 Sep 3;105(10):108104. Epub 2010 Sep 2.

Computational model for cell morphodynamics.

Author information

1
Center for Theoretical Biological Physics and Department of Physics, University of California, San Diego, La Jolla, California 92093-0374, USA.

Abstract

We develop a computational model, based on the phase-field method, for cell morphodynamics and apply it to fish keratocytes. Our model incorporates the membrane bending force and the surface tension and enforces a constant area. Furthermore, it implements a cross-linked actin filament field and an actin bundle field that are responsible for the protrusion and retraction forces, respectively. We show that our model predicts steady state cell shapes with a wide range of aspect ratios, depending on system parameters. Furthermore, we find that the dependence of the cell speed on this aspect ratio matches experimentally observed data.

PMID:
20867552
PMCID:
PMC3048783
DOI:
10.1103/PhysRevLett.105.108104
[Indexed for MEDLINE]
Free PMC Article

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