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Phys Rev Lett. 2010 Jun 11;104(23):238102. Epub 2010 Jun 8.

Bacterial chromosomal loci move subdiffusively through a viscoelastic cytoplasm.

Author information

1
Department of Biochemistry, Stanford University, Stanford, California 94305, USA.

Abstract

Tracking of fluorescently labeled chromosomal loci in live bacterial cells reveals a robust scaling of the mean square displacement (MSD) as τ(0.39). We propose that the observed motion arises from relaxation of the Rouse modes of the DNA polymer within the viscoelastic environment of the cytoplasm. The time-averaged and ensemble-averaged MSD of chromosomal loci exhibit ergodicity, and the velocity autocorrelation function is negative at short time lags. These observations are most consistent with fractional Langevin motion and rule out a continuous time random walk model as an explanation for anomalous motion in vivo.

PMID:
20867274
PMCID:
PMC4929007
DOI:
10.1103/PhysRevLett.104.238102
[Indexed for MEDLINE]
Free PMC Article

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