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Phys Rev Lett. 2010 May 28;104(21):218101. Epub 2010 May 24.

Aspiration of biological viscoelastic drops.

Author information

1
UMR 168, Institut Curie/CNRS, Université Pierre et Marie Curie, 75248 Paris, France.

Abstract

Spherical cellular aggregates are in vitro systems to study the physical and biophysical properties of tissues. We present a novel approach to characterize the mechanical properties of cellular aggregates using a micropipette aspiration technique. We observe an aspiration in two distinct regimes: a fast elastic deformation followed by a viscous flow. We develop a model based on this viscoelastic behavior to deduce the surface tension, viscosity, and elastic modulus. A major result is the increase of the surface tension with the applied force, interpreted as an effect of cellular mechanosensing.

PMID:
20867138
DOI:
10.1103/PhysRevLett.104.218101
[Indexed for MEDLINE]

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