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Bioorg Med Chem Lett. 2010 Nov 15;20(22):6850-3. doi: 10.1016/j.bmcl.2010.08.058. Epub 2010 Aug 15.

Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.

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1
PanThera Biopharma, LLC, Aiea, HI 96701, USA.

Abstract

Sub-nanomolar small molecule inhibitors of anthrax lethal factor have been identified using SAR and Merck L915 (4) as a model compound. One of these compounds (16) provided 100% protection in a rat lethal toxin model of anthrax disease.

PMID:
20864339
PMCID:
PMC2965585
DOI:
10.1016/j.bmcl.2010.08.058
[Indexed for MEDLINE]
Free PMC Article
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