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Int Immunopharmacol. 2010 Nov;10(11):1474-6. doi: 10.1016/j.intimp.2010.08.021. Epub 2010 Sep 21.

Sublingual immunotherapy may affect serum neopterin: preliminary findings.

Author information

1
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy. gio.cip@libero.it

Abstract

BACKGROUND:

Neopterin is a protein produced by monocytes/macrophages. It has been considered a biomarker of immune activation in several disorders. However, there are few studies in allergic rhinitis (AR). This study evaluated the serum neopterin levels in patients with pollen-induced AR or treated with sublingual immunotherapy (SLIT) and in healthy subjects.

METHODS:

146 subjects (70 males, median age 30.5 years): 56 with moderate-severe persistent AR, 40 with AR and successfully treated with 2 year SLIT, and 50 healthy controls were consecutively evaluated outside the pollen season. A skin prick test and blood sampling for assessing serum neopterin levels were performed in all subjects.

RESULTS:

SLIT-treated patients had lower neopterin levels than untreated patients and healthy subjects (respectively p=0.012 and p=0.0001).

CONCLUSIONS:

Neopterin is a biomarker for immune activation, SLIT may affect serum neopterin probably as a consequence of Treg response to SLIT.

PMID:
20863918
DOI:
10.1016/j.intimp.2010.08.021
[Indexed for MEDLINE]

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