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Trends Biochem Sci. 2010 Dec;35(12):669-75. doi: 10.1016/j.tibs.2010.07.003. Epub 2010 Sep 20.

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.

Author information

1
Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA. everdin@gladstone.ucsf.edu

Abstract

Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1-7) that modulate distinct metabolic and stress response pathways. Three sirtuins, SIRT3, SIRT4 and SIRT5, are located in the mitochondria, dynamic organelles that function as the primary site of oxidative metabolism and play crucial roles in apoptosis and intracellular signaling. Recent findings have shed light on how the mitochondrial sirtuins function in the control of basic mitochondrial biology, including energy production, metabolism, apoptosis and intracellular signaling.

PMID:
20863707
PMCID:
PMC2992946
DOI:
10.1016/j.tibs.2010.07.003
[Indexed for MEDLINE]
Free PMC Article

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