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Biochem Soc Trans. 2010 Oct;38(5):1242-6. doi: 10.1042/BST0381242.

Systems-level feedback in cell-cycle control.

Author information

1
Oxford Centre for Integrative Systems Biology, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK. bela.novak@bioch.ox.ac.uk

Erratum in

  • Biochem Soc Trans. 2010 Dec;38(6):1723.

Abstract

Alternation of chromosome replication and segregation is essential for successful completion of the cell cycle and it requires an oscillation of Cdk1 (cyclin-dependent kinase 1)-CycB (cyclin B) activity. In the present review, we illustrate the essential features of checkpoint controlled and uncontrolled cell-cycle oscillations by using mechanical metaphors. Despite variations in the molecular details of the oscillatory mechanism, the underlying network motifs responsible for the oscillations are always well-conserved. The checkpoint-controlled cell cycles are always driven by a negative-feedback loop amplified by double-negative feedbacks (antagonism).

PMID:
20863292
DOI:
10.1042/BST0381242
[Indexed for MEDLINE]
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