Format

Send to

Choose Destination
See comment in PubMed Commons below
J Biomed Biotechnol. 2010;2010. pii: 684504. doi: 10.1155/2010/684504. Epub 2010 Aug 25.

Endocrine disruptors and Leydig cell function.

Author information

1
Department of Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute & University Hospital, Q2:08, E-17176 Stockholm, Sweden. konstantin.svechnikov@ki.se

Abstract

During the past decades, a large body of information concerning the effects of endocrine disrupting compounds (EDCs) on animals and humans has been accumulated. EDCs are of synthetic or natural origin and certain groups are known to disrupt the action of androgens and to impair the development of the male reproductive tract and external genitalia. The present overview describes the effects of the different classes of EDCs, such as pesticides, phthalates, dioxins, and phytoestrogens, including newly synthesized resveratrol analogs on steroidogenesis in Leydig cells. The potential impact of these compounds on androgen production by Leydig cells during fetal development and in the adult age is discussed. In addition, the possible role of EDCs in connection with the increasing frequency of abnormalities in reproductive development in animals and humans is discussed.

PMID:
20862379
PMCID:
PMC2938463
DOI:
10.1155/2010/684504
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Hindawi Publishing Corporation Icon for PubMed Central
    Loading ...
    Support Center