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Eur J Clin Microbiol Infect Dis. 1990 Nov;9(11):827-30.

Isolation of Enterobacter aerogenes susceptible to beta-lactam antibiotics despite high level beta-lactamase production.

Author information

1
Veterans Administration Medical Center, Section of Infectious Diseases, Omaha, Nebraska 68105.

Abstract

This report describes a patient with nosocomial meningitis from whom four distinct isolates of Enterobacter aerogenes were recovered over a complicated course of chemotherapy. The initial isolate was susceptible to expanded spectrum beta-lactams despite constitutive production of high levels of beta-lactamase. Resistant isolates recovered during antibiotic therapy had lost a 42,000 outer membrane protein. These data suggest that b-lactam susceptibility in the original isolate was due to "hyperpermeability" mediated by the 42,000 Dalton protein.

PMID:
2086219
DOI:
10.1007/bf01967384
[Indexed for MEDLINE]

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