Format

Send to

Choose Destination
See comment in PubMed Commons below
J Stem Cells. 2010;5(1):23-31. doi: jsc.2010.5.1.23.

Immunological control of adult neural stem cells.

Author information

1
Neuroscience Laboratory, Psychology School, University of Colima, Colima, Mexico 28040. osglez@gmail.com

Abstract

Adult neurogenesis occurs only in discrete regions of adult central nervous system: the subventricular zone and the subgranular zone. These areas are populated by adult neural stem cells (aNSC) that are regulated by a number of molecules and signaling pathways, which control their cell fate choices, survival and proliferation rates. For a long time, it was believed that the immune system did not exert any control on neural proliferative niches. However, it has been observed that many pathological and inflammatory conditions significantly affect NSC niches. Even more, increasing evidence indicates that chemokines and cytokines play an important role in regulating proliferation, cell fate choices, migration and survival of NSCs under physiological conditions. Hence, the immune system is emerging is an important regulator of neurogenic niches in the adult brain, which may have clinical relevance in several brain diseases.

PMID:
20861925
PMCID:
PMC2946325
DOI:
jsc.2010.5.1.23
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center