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Bioinformatics. 2010 Nov 15;26(22):2924-6. doi: 10.1093/bioinformatics/btq538. Epub 2010 Sep 21.

DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene-disease networks.

Author information

1
Research Programme on Biomedical Informatics (GRIB) IMIM, DCEXS, Universitat Pompeu Fabra, C/Dr. Aiguader 88, 08003 Barcelona, Spain.

Abstract

DisGeNET is a plugin for Cytoscape to query and analyze human gene-disease networks. DisGeNET allows user-friendly access to a new gene-disease database that we have developed by integrating data from several public sources. DisGeNET permits queries restricted to (i) the original data source, (ii) the association type, (iii) the disease class or (iv) specific gene(s)/disease(s). It represents gene-disease associations in terms of bipartite graphs and provides gene centric and disease centric views of the data. It assists the user in the interpretation and exploration of the genetic basis of human diseases by a variety of built-in functions. Moreover, DisGeNET permits multicolouring of nodes (genes/diseases) according to standard disease classification for expedient visualization.

AVAILABILITY:

DisGeNET is compatible with Cytoscape 2.6.3 and 2.7.0, please visit http://ibi.imim.es/DisGeNET/DisGeNETweb.html for installation guide, user tutorial and download.

PMID:
20861032
DOI:
10.1093/bioinformatics/btq538
[Indexed for MEDLINE]

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