Format

Send to

Choose Destination
See comment in PubMed Commons below
Drug Metab Rev. 2011 Feb;43(1):1-26. doi: 10.3109/03602532.2010.515222. Epub 2010 Sep 23.

Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.

Author information

1
Department of Cellular and Molecular Pharmacology, The Liver Center, University of California, San Francisco, 94158, USA. almira.correia@ucsf.edu

Abstract

Heme is vital to our aerobic universe. Heme cellular content is finely tuned through an exquisite control of synthesis and degradation. Heme deficiency is deleterious to cells, whereas excess heme is toxic. Most of the cellular heme serves as the prosthetic moiety of functionally diverse hemoproteins, including cytochromes P450 (P450s). In the liver, P450s are its major consumers, with >50% of hepatic heme committed to their synthesis. Prosthetic heme is the sine qua non of P450 catalytic biotransformation of both endo- and xenobiotics. This well-recognized functional role notwithstanding, heme also regulates P450 protein synthesis, assembly, repair, and disposal. These less well-appreciated aspects are reviewed herein.

PMID:
20860521
PMCID:
PMC3034403
DOI:
10.3109/03602532.2010.515222
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center