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Chem Biodivers. 2010 Sep;7(9):2289-95. doi: 10.1002/cbdv.200900173.

Bioactive triterpenoids from Kadsura heteroclita.

Author information

1
Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, No. 151 Malianwa North Road, Haidian District, Beijing, P. R. China.

Abstract

A phytochemical study of Kadsura heteroclita led to the isolation of eight triterpenoids, including two new compounds, named kadheterilactone A (1) and kadheterilactone B (2), as well as six known compounds, longipedlactone H (3), longipedlactone A (4), longipedlactone F (5), kadsuranic acid A (6), nigranoic acid (7), and schisandronic acid (8). Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. The cytotoxic activities of 1-8 were tested against several tumor cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide (MTT) assay in vitro. As a result, 4 and 5 turned out to be significantly cytotoxic against Hep-G2 and Bel-7402 tumor cell lines. All compounds were also tested for inhibition on HIV-1 protease (PR) and reverse transcriptase (RT). Compounds 6 and 7 showed strong inhibition on HIV-1 PR, while 8 exhibited moderate activity, others were only weakly active. No compounds were active against HIV-1 RT.

PMID:
20860030
DOI:
10.1002/cbdv.200900173
[Indexed for MEDLINE]

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