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J Affect Disord. 2011 Jan;128(1-2):112-9. doi: 10.1016/j.jad.2010.06.013. Epub 2010 Sep 21.

Child Mania Rating Scale-Parent Version: a valid measure of symptom change due to pharmacotherapy.

Author information

1
University of Illinois at Chicago, Chicago, IL 60608, United States. awest@psych.uic.edu

Abstract

BACKGROUND:

The development of valid parent-report measures of symptom change in pediatric bipolar disorder (PBD) is imperative to evaluate the effectiveness of different treatment approaches; yet, few studies have tested the sensitivity of symptom measures. The current study evaluated the sensitivity of the Child Mania Rating Scale (CMRS-P) to detect symptom change over time in a treatment study for PBD.

METHODS:

Data on symptom change were drawn from a prospective six-week, double-blind, placebo-controlled, randomized outpatient medication treatment trial of risperidone versus divalproex. The sample included 66 children with Bipolar type I disorder. Measures were administered every week for six weeks of treatment.

RESULTS:

The CMRS-P demonstrated statistically (p ≤ .05) and clinically significant change in symptom report from pre to post-test. Growth curve modeling indicated that the CMRS-P demonstrated overall similarity to the YMRS in the magnitude and trajectory of change over time. Finally, results indicate that the CMRS-P is able to detect response rates with moderate levels of agreement with other measures.

LIMITATIONS:

Limitations of this study include a relatively small sample size and uncertain generalizability beyond treatment trials.

CONCLUSIONS:

The CMRS-P is short, easy to administer, and represents parent's report of symptoms, all strengths which make it a compelling treatment outcome tool. This preliminary evidence of its validity as a treatment outcome measure makes it applicable in other research settings and suggests its potential use in clinical settings.

PMID:
20858565
PMCID:
PMC2994944
DOI:
10.1016/j.jad.2010.06.013
[Indexed for MEDLINE]
Free PMC Article

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