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Antimicrob Agents Chemother. 2010 Dec;54(12):5406-12. doi: 10.1128/AAC.00580-10. Epub 2010 Sep 20.

LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus.

Author information

1
Eastern New Mexico University, Department of Biology, Station 33, Portales, NM 88130, USA.

Abstract

A multidrug efflux pump designated LmrS (lincomycin resistance protein of Staphylococcus aureus), belonging to the major facilitator superfamily (MFS) of transporters, was cloned, and the role of LmrS in antimicrobial efflux was evaluated. The highest relative increase in MIC, 16-fold, was observed for linezolid and tetraphenylphosphonium chloride (TPCL), followed by an 8-fold increase for sodium dodecyl sulfate (SDS), trimethoprim, and chloramphenicol. LmrS has 14 predicted membrane-spanning domains and is homologous to putative lincomycin resistance proteins of Bacillus spp., Lactobacillus spp., and Listeria spp.

PMID:
20855745
PMCID:
PMC2981259
DOI:
10.1128/AAC.00580-10
[Indexed for MEDLINE]
Free PMC Article

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