Format

Send to

Choose Destination
Eur J Immunol. 2010 Aug;40(8):2123-30. doi: 10.1002/eji.201040630.

Dendritic cells in cancer immunotherapy.

Author information

1
Department of Dermatology, University Hospital Erlangen, Erlangen, Germany. gerold.schuler@uk-erlangen.de

Abstract

DC initiate and regulate T-cell immunity and are thus the key to optimization of all types of vaccines. Insights into DC biology offer many opportunities to enhance immunogenicity. In this Viewpoint, I discuss some recent developments and findings that are of immediate relevance for the clinical development of cancer vaccines. In addition, I emphasize my personal view that we should explore the potential of adoptively transferred DC (i.e. DC vaccination) as cancer vaccines by performing two-armed trials that address critical variables and by delivering antigens via mRNA-transfected DC.

PMID:
20853498
DOI:
10.1002/eji.201040630
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center