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Org Biomol Chem. 2010 Dec 21;8(24):5486-9. doi: 10.1039/c0ob00579g. Epub 2010 Sep 20.

Mutanobactin A from the human oral pathogen Streptococcus mutans is a cross-kingdom regulator of the yeast-mycelium transition.

Author information

1
Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, OK 73019, USA.

Abstract

The recent investigation of a gene cluster encoding for a hybrid PKS-NRPS metabolite in the oral pathogen Streptococcus mutans UA159 yielded evidence that this natural product might play an important role regulating a range of stress tolerance factors. We have now characterized the major compound generated from this gene cluster, mutanobactin A, and demonstrated that this secondary metabolite is also capable of influencing the yeast-mycelium transition of Candida albicans.

PMID:
20852771
PMCID:
PMC2992086
DOI:
10.1039/c0ob00579g
[Indexed for MEDLINE]
Free PMC Article

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