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Curr Opin Genet Dev. 2010 Dec;20(6):605-12. doi: 10.1016/j.gde.2010.08.006. Epub 2010 Sep 28.

Frequency control of cell cycle oscillators.

Author information

1
The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

Abstract

The cell cycle oscillator, based on a core negative feedback loop and modified extensively by positive feedback, cycles with a frequency that is regulated by environmental and developmental programs to encompass a wide range of cell cycle times. We discuss how positive feedback allows frequency tuning, how size and morphogenetic checkpoints regulate oscillator frequency, and how extrinsic oscillators such as the circadian clock gate cell cycle frequency. The master cell cycle regulatory oscillator in turn controls the frequency of peripheral oscillators controlling essential events. A recently proposed phase-locking model accounts for this coupling.

PMID:
20851595
PMCID:
PMC3522487
DOI:
10.1016/j.gde.2010.08.006
[Indexed for MEDLINE]
Free PMC Article

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