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Curr Opin Genet Dev. 2010 Dec;20(6):670-6. doi: 10.1016/j.gde.2010.08.004. Epub 2010 Sep 17.

Oscillatory control of signalling molecules.

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Centre for Cell Imaging, School of Biological Sciences, The Biosciences Building, University of Liverpool, Crown St., Liverpool L69 7ZB, UK.


The emergence of biological function from the dynamic control of cellular signalling molecules is a fundamental process in biology. Key questions include: How do cells decipher noisy environmental cues, encode these signals to control fate decisions and propagate information through tissues? Recent advances in systems biology, and molecular and cellular biology, exemplified by analyses of signalling via the transcription factor Nuclear Factor kappaB (NF-κB), reveal a critical role of oscillatory control in the regulation of these biological functions. The emerging view is that the oscillatory dynamics of signalling molecules and the epigenetically regulated specificity for target genes contribute to robust regulation of biological function at different levels of cellular organisation through frequency-dependent information encoding.

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