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Curr Opin Immunol. 2010 Oct;22(5):609-15. doi: 10.1016/j.coi.2010.08.006. Epub 2010 Sep 17.

Antigen-specific immunotherapy of autoimmune and allergic diseases.

Author information

1
School of Cellular and Molecular Medicine, University of Bristol, Medical Sciences Building, University Walk, Bristol, BS8 1TD, UK.

Abstract

Nearly a century has passed since the first report describing antigen-specific immunotherapy (antigen-SIT) was published. Research into the use of antigen-SIT in the treatment of both allergic and autoimmune disease has increased dramatically since, although its mechanism of action is only slowly being unravelled. It is clear though, from recent studies, that success of antigen-SIT depends on the induction of regulatory T (T reg) cell subsets that recognise potentially disease-inducing epitopes. The major challenge remaining for the widespread use of antigen-SIT is to safely administer high doses of immunodominant and potentially pathogenic epitopes in a manner that induces T cell tolerance rather than activation. This review illustrates that intelligent design of treatment agents and strategies can lead to the development of safe and effective antigen-SIT.

PMID:
20850958
PMCID:
PMC2977065
DOI:
10.1016/j.coi.2010.08.006
[Indexed for MEDLINE]
Free PMC Article

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