Format

Send to

Choose Destination
See comment in PubMed Commons below
Epilepsy Behav. 2011 Feb;20(2):214-22. doi: 10.1016/j.yebeh.2010.08.004. Epub 2010 Sep 17.

Functional MRI is a valid noninvasive alternative to Wada testing.

Author information

1
Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. jbinder@mcw.edu

Abstract

Partial removal of the anterior temporal lobe (ATL) is a highly effective surgical treatment for intractable temporal lobe epilepsy, yet roughly half of patients who undergo left ATL resection show a decline in language or verbal memory function postoperatively. Two recent studies demonstrate that preoperative fMRI can predict postoperative naming and verbal memory changes in such patients. Most importantly, fMRI significantly improves the accuracy of prediction relative to other noninvasive measures used alone. Addition of language and memory lateralization data from the intracarotid amobarbital (Wada) test did not improve prediction accuracy in these studies. Thus, fMRI provides patients and practitioners with a safe, noninvasive, and well-validated tool for making better-informed decisions regarding elective surgery based on a quantitative assessment of cognitive risk.

PMID:
20850386
PMCID:
PMC3008762
DOI:
10.1016/j.yebeh.2010.08.004
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center