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Am J Transplant. 2010 Nov;10(11):2493-501. doi: 10.1111/j.1600-6143.2010.03271.x. Epub 2010 Sep 17.

Transplantation outcomes in primary hyperoxaluria.

Collaborators (161)

Adey D, Ahmed S, Aigbe M, Alexander S, Anders M, Amin N, Ashette, Asplin JR, Azam N, Balakrishnan N, Bhandare S, Baum M, Becker B, Beckman D, Beiken, Belani S, Bellucci A, Berkseth R, Berry P, Bhakta N, Bhat A, Bhupalam S, Bia M, Blydt-Hansen T, Bousquet R, Braun M, Brewer E, Brueggmeyer C, Bunchman T, Butani L, Cadnapaphornchai M, Castillo-Velarde Lima E, Choi MJ, Chybowski F, Ciuitarese F, Copelovitch L, Corbin F, Corey H, Creemers D, Cunningham R, Dalinghaus K, Davis I, de Souza C, DeBeukelaer M, Delaney V, Devarajan P, Dolezel Z, Doll HA, Douville P, Ecklund S, Eidman K, Emmett M, Ford D, Foreman J, Fritsche C, Garcia S, Geary D, Gipson D, Goldfarb D, Greco B, Greenbaum L, Haley W, Hall P, Hames M, Hanevold CD, Harris F, Hart G, Harvey E, Heilman RL, Helman R, Herndon A, Herrin J, Hertl M, Hidalgo G, Hmiel S, Hoppe B, Hotchkiss H, Hunley T, Husmann D, Johnston J, Kaiser B, Kannapadi U, Kashani C, Kaskel F, Kendrick E, Khan O, Knohl S, Kossman R, Krambeck A, Langman C, Larch L, Leiser J, Lerman S, Levy DL, Lingeman J, Lirenman DS, Maalouf N, Maddy M, Mansell MA, Martin M, Mathias R, Mauer M, May M, McHugh M, Metcalfe P, Morgenstern B, Murphy G, Narkewicz M, Navarro M, Pohl HG, Powell H, Randeree I, Rao V, Raskin D, Ravichandran, Restall L, Richardson C, Rocklin M, Sacks P, Sanderson M, Scandling JD, Sharma J, Sheehan M, Sievers K, Simon E, Sirota R, Smith C, Sobel M, Somasundaram D, Starzl T, Steinke J, Steward D, Suarez M, Symons JM, Tang IY, Tariq J, Teruel M, Tolaymat A, Tomsho MM, Torres A, Tuchman S, Turman MA, Unwin R, Venick R, Venkatesh S, Vera A, Viko H, Villa R, Wang J, Warady B, Warshaw B, Weimer C, Weinstein J, Weiss RA, Wertsch P, Wesson J, Wong C, Wong W, Worcester E, Yadin O, Yiu V.

Author information

1
Division of Biomedical Statistics and Informatics, Departments of Pediatrics and Internal Medicine, Mayo Clinic Hyperoxaluria Center, 200 First Street SW, Rochester, MN 55905, USA.

Abstract

Optimal transplantation strategies are uncertain in primary hyperoxaluria (PH) due to potential for recurrent oxalosis. Outcomes of different transplantation approaches were compared using life-table methods to determine kidney graft survival among 203 patients in the International Primary Hyperoxaluria Registry. From 1976-2009, 84 kidney alone (K) and combined kidney and liver (K + L) transplants were performed in 58 patients. Among 58 first kidney transplants (32 K, 26 K + L), 1-, 3- and 5-year kidney graft survival was 82%, 68% and 49%. Renal graft loss occurred in 26 first transplants due to oxalosis in ten, chronic allograft nephropathy in six, rejection in five and other causes in five. Delay in PH diagnosis until after transplant favored early graft loss (p = 0.07). K + L had better kidney graft outcomes than K with death-censored graft survival 95% versus 56% at 3 years (p = 0.011). Among 29 year 2000-09 first transplants (24 K + L), 84% were functioning at 3 years compared to 55% of earlier transplants (p = 0.05). At 6.8 years after transplantation, 46 of 58 patients are living (43 with functioning grafts). Outcomes of transplantation in PH have improved over time, with recent K + L transplantation highly successful. Recurrent oxalosis accounted for a minority of kidney graft losses.

PMID:
20849551
PMCID:
PMC2965313
DOI:
10.1111/j.1600-6143.2010.03271.x
[Indexed for MEDLINE]
Free PMC Article

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