Revisiting the Kinnel-Scheuer hypothesis for the biosynthesis of palau'amine

Chem Commun (Camb). 2011 Jan 7;47(1):427-9. doi: 10.1039/c0cc02214d. Epub 2010 Sep 16.

Abstract

We propose herein an alternative biosynthetic pathway for palau'amine in order to resolve the stereochemical issue from the original Kinnel-Scheuer hypothesis. Furthermore, we use this revised hypothesis as a guide toward the laboratory synthesis of palau'amine.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Molecular Structure
  • Peptides, Cyclic / biosynthesis
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Stereoisomerism

Substances

  • Peptides, Cyclic
  • palauamide