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Curr Opin Cell Biol. 2010 Dec;22(6):889-95. doi: 10.1016/j.ceb.2010.08.022. Epub 2010 Sep 16.

Distinct death mechanisms in Drosophila development.

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1
Department of Cell Biology, New York University, New York, NY 10016, USA. Hyungdon.Ryoo@nyumc.org

Abstract

Apoptosis and autophagic cell death occur during Drosophila development, and recent advances in their mechanisms have been made. As in other organisms, apoptosis is executed by caspases. In living cells, caspases are kept in check through a combination of IAP-binding and proteolytic inhibition. Once a cell commits to apoptosis, phagocytes recognize them through the immuno-receptor-like proteins Draper and Simu, and initiate corpse engulfment. Drosophila research has significantly contributed to the idea that autophagy is required for certain forms of cell death, and that caspase function in autophagic cell death depends on cell context. Surprisingly, the cell corpse engulfment receptor Draper also functions in autophagic cell death. These advances facilitate our understanding of the cell death mechanisms in development and disease.

PMID:
20846841
PMCID:
PMC2993842
DOI:
10.1016/j.ceb.2010.08.022
[Indexed for MEDLINE]
Free PMC Article
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