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Br J Cancer. 2010 Sep 28;103(7):1093-6. doi: 10.1038/sj.bjc.6605782. Epub 2010 Sep 14.

Smoking cessation and lung cancer risk in an Asian population: findings from the Singapore Chinese Health Study.

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1
Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore.

Abstract

BACKGROUND:

Smoking cessation is an important strategy for reducing the harmful effects of tobacco, particularly in the prevention of lung cancer; however, prospective data on the impact of smoking cessation on lung cancer risk in Asian populations are limited.

METHODS:

We studied a population-based cohort of Chinese men and women aged 45-74 years--participants of the Singapore Chinese Health Study. Information on smoking, lifestyle and dietary habits was collected at the time of recruitment in 1993-1998; and smoking status was assessed again at a second interview in 1999-2004 (mean interval 5.8 years). Participants were followed up to 31 December 2007, and incident cases of lung cancer were ascertained by linkage with population-wide registries.

RESULTS:

Among 45,900 participants, there were 463 incident cases of lung cancer. Relative to current smokers, those who quit smoking subsequent to baseline assessment had a 28% decrease in the risk of lung cancer (adjusted hazard ratio (HR) 0.72; 95% CI (95% confidence interval): 0.53-0.98). The risk was less than half in ex-smokers who had quit before the first interview and maintained their status (HR 0.42; 95% CI: 0.32-0.56).

CONCLUSIONS:

Reduction in lung cancer incidence with smoking cessation in Asian populations is substantial and can be observed within a few years after quitting.

PMID:
20842124
PMCID:
PMC2965852
DOI:
10.1038/sj.bjc.6605782
[Indexed for MEDLINE]
Free PMC Article
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