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Br J Cancer. 2010 Sep 28;103(7):1081-4. doi: 10.1038/sj.bjc.6605877. Epub 2010 Sep 14.

Risk of breast cancer according to clinicopathologic features among long-term survivors of Hodgkin's lymphoma treated with radiotherapy.

Author information

1
Medical Service, Department of Veterans Affairs Medical Center, 921 N.E. 13th Street, Oklahoma City, OK 73104, USA. doresg@mail.nih.gov

Abstract

BACKGROUND:

It is unknown whether breast cancer (BC) characteristics among young women treated with radiotherapy (RT) for Hodgkin's lymphoma (HL) differ from sporadic BC.

METHODS:

Using population-based data, we calculated BC risk following HL according to clinicopathologic features.

RESULTS:

Compared with BC in the general population, risks of oestrogen receptor (ER)-positive/progesterone receptor (PR)-positive and ER-negative/PR-negative BC in young, irradiated HL survivors were increased five-fold (95% confidence interval (CI)=3.81-6.35) and nine-fold (95% CI=6.93-12.25), respectively. Among 15-year survivors, relative risk of ER-negative/PR-negative BC exceeded by two-fold (P=0.002) than that of ER-positive/PR-positive BC.

CONCLUSION:

Radiotherapy may disproportionately contribute to the development of BC with adverse prognostic features among young HL survivors.

PMID:
20842115
PMCID:
PMC2965878
DOI:
10.1038/sj.bjc.6605877
[Indexed for MEDLINE]
Free PMC Article

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