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Eur Arch Paediatr Dent. 2010 Aug;11(4):187-91.

Saliva profiles in children using heart failure medication: a pilot study.

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Paediatric Dentistry, Department of Odontology, Faculty of Medicine, Umeå University, SE 901 87 Umeå, Sweden.

Erratum in

  • Eur Arch Paediatr Dent. 2010 Oct;11(5):262.



To study the saliva profiles in children with severe heart disease taking heart failure medication compared with the saliva from healthy age and gender matched controls.


Cross sectional case-control design.


Twenty-four age and gender matched pairs of children, mean age 12.0 years participated. Stimulated saliva was collected in a standardized way before lunchtime and the subjects were asked to refrain from all eating, drinking and tooth brushing 90 mins before sampling. Stimulated salivary secretion rate, buffering capacity, total salivary viable count of bacteria, mutans streptococci and lactobacilli, calcium, chloride, magnesium, potassium, sodium and salivary IgA were determined.


There were 7 of the 24 children in the cardiac group who had secretions below 0.5 ml/min compared with no child in the control group (p<0.01). Lower [corrected] total viable counts of bacteria (TVC) were detected in the cardiac group 1.4x10⁶ ± 1.2x10⁷ vs. 2.7x10⁶ ± 2.9x10⁷ in the control group (p<0.05). Mutans streptococci (MS) in the cardiac group were 5.2x10⁴ ± 1.5x10⁵ vs. 8.1 x10³ ± 1.3x10⁴ in the control group, (p>0.05) and MS ratio of TVC constituted 0.11±0.35 per cent compared to 0.01±0.02 per cent for the control group (p>0.05).


Continuous data were analysed by an analysis of variance (ANOVA) and categorical data by chi-square test.


Reduced salivary secretion could be a caries risk factor in children taking heart failure medication.

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