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Chem Commun (Camb). 2010 Oct 28;46(40):7533-5. doi: 10.1039/c0cc01846e. Epub 2010 Sep 13.

Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin αvβ6 protein-peptide interactions.

Author information

1
Protein Science Group, School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK.

Abstract

We report the first example of peptide-protein heteronuclear two-dimensional (2D) saturation transfer difference nuclear magnetic resonance (STD NMR). This method, resulting in dramatically reduced overlap, was applied to the interaction of the integrin αvβ6 with a known peptide ligand and highlights novel contact points between the substrate and target protein.

PMID:
20838674
DOI:
10.1039/c0cc01846e
[Indexed for MEDLINE]

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