Format

Send to

Choose Destination
Free Radic Res. 2010 Oct;44(10):1098-124. doi: 10.3109/10715762.2010.498477.

Chemistry and biochemistry of lipid peroxidation products.

Author information

1
UMR1089 Xénobiotiques, INRA, Toulouse, France. fgueraud@toulouse.inra.fr

Abstract

Oxidative stress and resulting lipid peroxidation is involved in various and numerous pathological states including inflammation, atherosclerosis, neurodegenerative diseases and cancer. This review is focused on recent advances concerning the formation, metabolism and reactivity towards macromolecules of lipid peroxidation breakdown products, some of which being considered as 'second messengers' of oxidative stress. This review relates also new advances regarding apoptosis induction, survival/proliferation processes and autophagy regulated by 4-hydroxynonenal, a major product of omega-6 fatty acid peroxidation, in relationship with detoxication mechanisms. The use of these lipid peroxidation products as oxidative stress/lipid peroxidation biomarkers is also addressed.

PMID:
20836659
DOI:
10.3109/10715762.2010.498477
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center