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Chem Rec. 2010 Dec;10(6):366-76. doi: 10.1002/tcr.201000008. Epub 2010 Sep 10.

Nanogel engineering for new nanobiomaterials: from chaperoning engineering to biomedical applications.

Author information

1
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.

Abstract

Nanosize hydrogels (nanogels) are polymer nanoparticles with three-dimensional networks, formed by chemical and/or physical cross-linking of polymer chains. Recently, various nanogels have been designed, with a particular focus on biomedical applications. In this review, we describe recent progress in the synthesis of nanogels and nanogel-integrated hydrogels (nanogel cross-linked gels) for drug-delivery systems (DDS), regenerative medicine, and bioimaging. We also discuss chaperone-like functions of physical cross-linking nanogel (chaperoning engineering) and organic-inorganic hybrid nanogels.

PMID:
20836092
DOI:
10.1002/tcr.201000008
[Indexed for MEDLINE]

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