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Methods Mol Biol. 2010;673:1-17. doi: 10.1007/978-1-60761-842-3_1.

Sequencing and genome assembly using next-generation technologies.

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Center for Bioinformatics and Computational Biology, Institute for Advanced Computer Studies and Department of Computer Science, University of Maryland, College Park, MD, USA.


Several sequencing technologies have been introduced in recent years that dramatically outperform the traditional Sanger technology in terms of throughput and cost. The data generated by these technologies are characterized by generally shorter read lengths (as low as 35 bp) and different error characteristics than Sanger data. Existing software tools for assembly and analysis of sequencing data are, therefore, ill-suited to handle the new types of data generated. This paper surveys the recent software packages aimed specifically at analyzing new generation sequencing data.

[Indexed for MEDLINE]

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