Abstract
The Cu-catalyzed synthesis of skipped 1,4-dienes from allylic acetates and vinyl-Grignard reagents is key to bidirectional modifications of acyclic terpene acetates. As a result, trisubstituted double bond containing subunits can be readily transferred into complex polyketides from inexpensive bulk terpenes.
MeSH terms
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Catalysis
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Copper / chemistry
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Cyclohexenes / chemical synthesis
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Cyclohexenes / chemistry
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Macrolides / chemical synthesis*
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Macrolides / chemistry
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Molecular Structure
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Organometallic Compounds / chemistry
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Stereoisomerism
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Terpenes / chemistry*
Substances
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Cyclohexenes
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Macrolides
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Organometallic Compounds
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Terpenes
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1,4-cyclohexadiene
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Copper