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Virology. 2010 Nov 25;407(2):247-55. doi: 10.1016/j.virol.2010.08.008. Epub 2010 Sep 15.

Heterocellular induction of interferon by negative-sense RNA viruses.

Author information

1
School of Biology, Centre for Biomolecular Sciences, BMS Building, North Haugh, University of St. Andrews, St. Andrews, Fife, KY16 9ST, UK.

Abstract

The infection of cells by RNA viruses is associated with the recognition of virus PAMPs (pathogen-associated molecular patterns) and the production of type I interferon (IFN). To counter this, most, if not all, RNA viruses encode antagonists of the IFN system. Here we present data on the dynamics of IFN production and response during developing infections by paramyxoviruses, influenza A virus and bunyamwera virus. We show that only a limited number of infected cells are responsible for the production of IFN, and that this heterocellular production is a feature of the infecting virus as opposed to an intrinsic property of the cells.

PMID:
20833406
PMCID:
PMC2963793
DOI:
10.1016/j.virol.2010.08.008
[Indexed for MEDLINE]
Free PMC Article

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