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Mutat Res. 2010 Nov 28;703(1):11-7. doi: 10.1016/j.mrgentox.2010.08.021. Epub 2010 Sep 15.

Salvage of oxidized guanine derivatives in the (2'-deoxy)ribonucleotide pool as source of mutations in DNA.

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1
Division of Hematology and Oncology, Department of Internal Medicine, University of California Davis Medical Center, 4501 X Street, Suite 3016, Sacramento, CA 95817, USA. paul.henderson@ucdmc.ucdavis.edu

Abstract

Recent evidence suggests that salvage of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) and 8-oxo-7,8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of 8-oxoGua in DNA and RNA. However, it remains to be determined if this mechanism contributes to mutagenesis and disease. This review covers the predominant methods for detecting 8-oxoGua and its derivatives, summarizes some of the relevant recent DNA repair studies and discusses the mechanisms for metabolism of oxidized guanine derivatives in the (2'-deoxy)ribonucleoside and (2'-deoxy)ribonucleotide pools.

PMID:
20833264
PMCID:
PMC2991500
DOI:
10.1016/j.mrgentox.2010.08.021
[Indexed for MEDLINE]
Free PMC Article
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