Format

Send to

Choose Destination
See comment in PubMed Commons below
Int J Biochem Cell Biol. 2010 Dec;42(12):1931-5. doi: 10.1016/j.biocel.2010.08.019. Epub 2010 Sep 15.

Neuronal networks of nicotine addiction.

Author information

1
Facultad de Medicina, Universidad de Morón - Consejo Nacional de Investigaciones Científicas y Técnicas, Argentina.

Abstract

Nicotine is the main psychoactive substance present in tobacco, targeting neuronal nicotinic acetylcholine receptors. The main effects of nicotine associated with smoking are nicotinic receptor activation, desensitization, and upregulation, with the subsequent modulation of the mesocorticolimbic dopaminergic system. However, there is a lack of a comprehensive explanation of their roles that effectively makes clear how nicotine dependence might be established on those grounds. Receptor upregulation is an unusual effect for a drug of abuse, because theoretically this implies less need for drug consumption. Receptor upregulation and receptor desensitization are commonly viewed as opposite, homeostatic mechanisms. We here review the available information on smoking addiction, especially under a recently presented model of nicotine dependence. In this model both receptor upregulation and receptor desensitization are responsible for establishing a biochemical mechanism of nicotine dependence, which have an important role in starting and maintaining tobacco addiction.

PMID:
20833261
DOI:
10.1016/j.biocel.2010.08.019
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center