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Neurosci Lett. 2010 Nov 26;485(3):151-6. doi: 10.1016/j.neulet.2010.08.078. Epub 2010 Sep 15.

Alpha-conotoxin ImI disrupts central control of swimming in the medicinal leech.

Author information

1
Broad Fellows Program and Division of Biology, California Institute of Technology, 1200 E California Blvd 216-76, Pasadena, CA 91125, USA. daw@caltech.edu

Abstract

Medicinal leeches (Hirudo spp.) swim using a metachronal, front-to-back undulation. The behavior is generated by central pattern generators (CPGs) distributed along the animal's midbody ganglia and is coordinated by both central and peripheral mechanisms. Here we report that a component of the venom of Conus imperialis, α-conotoxin ImI, known to block nicotinic acetyl-choline receptors in other species, disrupts swimming. Leeches injected with the toxin swam in circles with exaggerated dorsoventral bends and reduced forward velocity. Fictive swimming in isolated nerve cords was even more strongly disrupted, indicating that the toxin targets the CPGs and central coordination, while peripheral coordination partially rescues the behavior in intact animals.

PMID:
20833225
PMCID:
PMC2956871
DOI:
10.1016/j.neulet.2010.08.078
[Indexed for MEDLINE]
Free PMC Article

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