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Bioorg Med Chem Lett. 2010 Nov 1;20(21):6246-9. doi: 10.1016/j.bmcl.2010.08.099. Epub 2010 Aug 24.

Investigation of 4-piperidinols as novel H3 antagonists.

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1
Athersys Inc., 3201 Carnegie Ave., Cleveland, OH 44115-2634, USA. andersj12@wyeth.com

Abstract

Compounds containing a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor. The compounds exhibited up to a 60-fold preference for inhibiting the human H(3) receptor over the mouse and showed a low binding affinity for the hERG channel.

PMID:
20833043
DOI:
10.1016/j.bmcl.2010.08.099
[Indexed for MEDLINE]
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